Top of the list is Y: The Last Man. The premise is basic but brilliant: Yorick Brown is (copy/pasting from the DC webpage now...) "the only human survivor of a planet-wide plague that instantly kills every mammal possessing a Y chromosome". The girls - realistically but somewhat disappointingly - don't handle the collective death of the entire male gender very well at all.
The narrative is long (there are, like, 60 issues in the series), but it carries you along like nothing else - both visually and in terms of the plot and dialogue. One of the reviewers said it best: "This year's best movie is a comic book."
If you promise not to BitTorrent it (like I did, for shame), then I'll tell you that the first issue is available for free download from DC.