In my online wanderings I stubbed my toe on a 1984 (the year, not the book) (maybe) essay by Thomas Pynchon called Is It OK To Be A Luddite?. It's a belated response/timely reassessment of CP Snowe's lecture, The Two Cultures and the Scientific Revolution, which was (quoting PYnchon now) "notable for its warning that intellectual life in the West was becoming polarized into "literary" and "scientific" factions, each doomed not to understand or appreciate the other."
Snowe's theory was eventually hit over the fence by Stephen Jay Gould, but Pynchon's essay is still well worth a read.
In typical style, he name-checks literary characters like Frankenstein and Brainy Smurf and funny-named real people like Ned Lud and Arnold Toynbee, talks (a lot) about the sciences, and then (even more) about the arts, and goes on long, rambling tangents where those two cultures don't just meet - they run away together for a dirty weekend in Mexico.